Tentative program for the ISPP 2019 Ion Channel Meeting 

Feb 13th, 2019 at Mishkenot Shaananim, Jerusalem

Organizing committee: Prof. Nathan Dascal, Prof. Bernard Attali, Prof. Ofer Yifrach, Dr. Avi Priel 


Throughout the meeting, each session will consist of three long (25 minutes) lectures presented by PIs and one short lecture (15 minutes) presented by research students and postdocs.


8:00-8:45 – Registration

8:45-9:00 –  Introduction: Prof. Nathan Dascal, ISPP president

9:00-10:30 – From fly to man: structure to function of channels

Chairs: Prof. Arie Moran (Ben-Gurion University), Prof. Baruch Minke (The Hebrew University)

Shai Berlin (Technion): NMDA-receptors dysfunction and epilepsy

Yoni Haitin  (Tel-Aviv University): Molecular insights into KCNH1 channels inhibition by Ca2+-calmodulin – implications for cellular proliferation

Arie Moran (Ben-Gurion University): ZnT-1; a new regulator of calcium channels: Physiology and pathophysiology

Rita Gutorov (The Hebrew University): Cholesterol and drosophila TRP channels.


10:30-10:45 – Coffee break


10:45-12:15 – Regulation of ligand-gated ion channels

Chair:  Prof. Yael Stern-Bach (The Hebrew University)

Millet Treinin (The Hebrew University): Regulation of nACh and GABAA receptors by RIC-3

Rami Yaka (The Hebrew University): Targeting AMPA receptors for memory eraser

Yael Stern-Bach (The Hebrew University):  Regulation of AMPA receptors by TARPs

Matan Geron (The Hebrew University): TRPV1 pore turret dictates distinct gating by different channel activators


12:15-13:00 – Lunch


13:00-14:30 – Ca2+channels

Chairs: Daphne Atlas (The Hebrew University) and Nathan Dascal (Tel-Aviv University)

Joel Hirsch (Tel-Aviv University): TBA

Raz Palti (Technion): Regulation of Ca2+release-activated Ca2+channels

Daphne Atlas (The Hebrew University): The β-subunit of the voltage-gated Ca2+channel Cav1.2 drives signaling to the nucleus via H-Ras

Moshe Katz (Tel-Aviv University): A potential novel mechanism of regulation of cardiac L-type Ca2+channel by PKA.


14:30-14:45 – Coffee break


14:45-16:15 – Pumps and transporters

Chairs: Prof. Daniel Khananshvili (Tel-Aviv University), Dr. Moshe Giladi (Tel-Aviv University)

Etana Padan (The Hebrew University): The NhaA Na+/H+antiporter, new insights into structural and functional dynamics

Steven Karlish (Weizmann Institute of Science): Specific lipid-protein interactions of Na/K-ATPase

Ehud Ohana (Ben-Gurion University): Pathologies of impaired metabolite transport

Bosmat Refaeli (Tel-Aviv University): Structure-dynamic and functional relationships in a Li+-transporting sodium-calcium exchanger mutant


16:15-16:30 – Coffee break


16:30-18:00 – Session 5

Arrhythmia and ion channels

Chairs: Prof. Bernard Attali (Tel-Aviv University), Prof. Yoram Etzion (Ben-Gurion University)

Shimrit Oz (Sheba Tel Hashomer): Ca2+-dependent mechanisms of cardiac sodium currents regulation

Lior Gepstein (Technion): Studying channelopathies with IPSCs

Bernard Attali (Tel-Aviv University): SK4 K+channel blockers: a new treatment for cardiac arrhythmias

Max Drabkin (Ben-Gurion University): Nocturnal atrial fibrillation caused by mutation in KCND2, encoding pore-forming (α) subunit of the cardiac Kv4.2 potassium channel